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SCIENCE OF restoreGen®

Well-being is hard-wired and dopamine is the key

Feelings of happiness depend in part on a person’s hard wiring in the brain. It is now known that feelings of well-being, are linked to a healthy normal function of how brain chemicals interact to produce the release of a hormone called dopamine. It is well known that dopamine helps regulate movement, attention, learning, and emotional responses. It also enables us not only to see rewards, but to take action to move toward them. This phenomenon is due to the neuronal release of dopamine at the reward site of the brain, Nucleus Accumbens (NAc). This involves a complicated cascade of events called the “Brain Reward Cascade” it can be represented by the associated figure.

brain reward cascade
happy and unhappy brain diagram

Regulation of a “Happy Brain” depends upon the activity of GABA

At least 110 million people in the United States of America are genetically prone to addictive-like behaviors and even thoughts. There are many genes involved in enabling our ability to perceive life positively and as such under normal genetic control it has been stated that we have a “Happy Brain.”  However, when the brain reward cascade is impaired due to either our genetic makeup (at birth) or our environment (especially when we are in a stressful life style etc.), the physiological workings of our brain is in an impaired state and as such we have an “Unhappy Brain.” The chemical messenger that regulates dopamine neuronal release is a powerful neurotransmitter called GABA. In essence, too much GABA leads to a reduction of dopamine with concomitant inability to cope with stress even within the family and loved ones. The figure below shows a schematic relating chemical messaging with amounts of dopamine being released at the reward site of the brain (NAc).

All addictions are classified as “Reward Deficiency Syndrome” (RDS)

Following extensive research by many world class scientists, a new understanding of addictive behaviors arose suggesting that alcoholism is similar to opiate, cocaine, nicotine, food addiction, and even certain repetitive behaviors (e.g. gambling, sex addiction, etc.), in terms of how these substances work in the brain to release dopamine. This expansion of the addiction definition is based on an understanding that both psychoactive drugs and certain behaviors that produce a surge of dopamine in the mid-brain are the biological substrate for addictive behavior. Individuals who are genetically predisposed to addiction are at higher risk for this “Reward Deficiency Syndrome” due to the interplay of genetic and environmental factors.

In essence, high risk individuals seek substances including alcohol, opiates, cocaine, nicotine, and/or glucose. These are all substances known to cause preferential release of dopamine at the NAc to activate dopaminergic pathways in order to offset their low D2 receptors, caused by at least one gene variant the dopamine D2 receptor gene Taq1 A1 allele antecedents. These behaviors include not only addictive but impulsive, compulsive and even personality.

The new definition of addiction

As newly defined by the American Society of Addiction Medicine (ASAM 2011), the United States’ Addiction Specialty Society of Physicians, addiction is a primary, chronic disease involving brain reward, motivation, memory and related circuitry. Dysfunction in these circuits leads to characteristic biological, psychological, social and spiritual manifestations. This is reflected in persons compulsively pursuing reward and/or relief by substance use and other behaviors. Addiction cannot be cured but can be brought into remission through a program of treatment, abstinence from all psychoactive substances, and supported recovery. Alcohol and other drugs have long been recognized as addictive substances and addiction is now generally recognized as a chronic disease of the brain that involves relapse, progressive development, and the potential for fatality if not treated. Impairment of the reward circuitry must be addressed to prevent relapse, support recovery, and enhance the quality of life.

The key is to naturally boost dopamine function at the reward site of the brain

While scientists in the pharmaceutical industry found ways to increase dopamine function in the reward site of the brain with very powerful drugs known as dopamine agonists, long-term administration results in a reduction instead of a boost of brain dopamine function lead to an “Unhappy Brain.”

However, following decades of research and 41 clinical trials, a novel natural complex known as restoreGen® (research code KB220Z and KB220PAM) has finally come to market especially for the millions of family members afflicted with RDS. The list of benefits is quite remarkable and includes:

  • positive recovery rates
  • prevention of addiction relapse
  • reduction of Against Medical Advice (AMA) rates
  • direct dopaminergic activation at the reward site of the brain
  • regulation of brain wave activity in the cingulate gyrus (relapse site of the brain) increasing alpha and increasing low beta bands
  • reduction of aberrant craving behavior
  • increased energy
  • enhanced focus and attention
  • most importantly enhanced feelings of well-being and happiness

What is the evidence that supports an enhanced dopamine sensitivity and a ”Happy Brain”?

restoreGen® (KB220Z and KB220PAM) is unlike any other product in the recovery market. restoreGen® has been extensively researched in human clinical settings (published over 41 peer reviewed studies). The mechanism of action (MOA) has been recently unraveled through specialized neuro-imaging analysis. One recent published study utilizing qEEG showed that one hour after administering restoreGen® to psychostimulant addicts, alcoholics, and heroin addicts, it resulted in smoothing out of disregulated PFC cingulated Gyrus. In essence, it was found that restoreGen® increased alpha and low beta waves in this important brain region. By doing so the neuro-nutrient compared to placebo (triple blinded), induced a regulation of brain electro-activity at a site that has been linked to reward relapse (e.g. drugs, smoking, sugar indulging etc.).

qEEG chart

In another study still in progress in China at Beijing University Imaging Center, abstinent Chinese heroin addicts were evaluated utilizing fMRI for effects of restoreGen® after one-hour of administration compared to placebo. It was found that restoreGen® relative to the placebo controlled (triple-blinded) inactive complex significantly activated reward site dopamine. This translates to providing a MOA whereby this natural substance acting as a dopamine D2 stimulate (agonist) reduces generalized craving behavior. This occurs by actually enhancing dopamine sensitivity at this important brain site overcoming dopamine resistance and concomitantly abnormal craving reduction. It is also noteworthy, that restoreGen® also reduced the hyperemotional state observed in an associated brain region (Putamen) inducing a “Happy Brain.”

It is well-known that stress is an important relapse culprit especially in those individuals predisposed to high risk behaviors carrying variant (compromised) dopaminergic genes (e.g. DRD2 gene A1 allele), leading to an inability to cope with stressful events. Thus, the importance of finding ways to manipulate the brain promoting enhanced “dopamine sensitivity” is equivalent to reduce relapse regarding drug abuse and other RDS behaviors. Double-blind-placebo-controlled studies utilizing the objective skin-conductance method conducted at an inpatient facility in Louisiana clearly showed that restoreGen® significantly reduces stress. This anti-stress response most likely due to the activation of brain reward dopamine sites, which occurred within the first seven patients in treatment. Thus, continued utilization of restoreGen® should reduce stress during recovery.

An important factor in relapse prevention is sound judgment and decision making to avoid harm

The consensus of the current neuroscience literature supports the notion that in the PFC-Cingulate Gyrus brain region (a site for executive functioning –decision making), normal dopamine function is associated with good judgment, sharp focus and positive cognitive abilities. In a study involving healthy volunteers, restoreGen® significantly enhanced focus and working memory following 30 days of treatment. This finding represents an important component supporting the view that restoreGen® will promote good decision making and as such be helpful in relapse prevention.

Through the activation of dopamine pathways in the brain, studies report that restoreGen® significantly reduces relapse in both drugs and food addiction

Since it has been adequately researched it is agreed that drug abuse and food abuse have similar common neurobiological and genetic antecedents. As such, both have been considered to be part of “Reward Deficiency Syndrome” (RDS) and involve “dopamine resistance.” To overcome relapse a number of published studies show unequivocally that restoreGen® attenuates relapse in alcoholics, heroin and cocaine addicts and even in over-eaters. This phenomenon is due to an understanding that restoreGen® is the only known dopamine activator without side effects and is providing thousands of recovering families significant relief and a better quality of life during recovery in conjunction with good diet, exercise (yoga, meditation, talk & music therapy and 12 step program, fellowship or other self-help fellowships) through the release of dopamine at both the reward and relapse sites of the brain.

purple and green relapse chart
naat benefits chart

What are the primary benefits of restoreGen®?

We have identified through rigor and diligence a number of important clinical benefits of this dopamine-regulated “Medical Food” called Neuroadopamineptagen Amino-Acid Therapy (NAAT). For a summary of these proven benefits see below. The remarkable list is due to the amazing role of dopamine in the reward circuits of the brain regulating everything from carbohydrate intake, drug seeking behavior, energy production, memory/focus and an overall sense of well-being.

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